1p31.3. View the map and BAC clones (data from UCSC genome browser).
DOCK7 (NM_033407): 49 exons, 233,573 bp, chr1:62,692,985-62,926,557.
The figure below shows the structure of the DOCK7 gene (data from UCSC genome browser).
View NCBI HomoloGene of DOCK7.
Two domains are shared amongst all DOCK proteins, the catalytic DHR-2 (DOCK homology region 2) or CZH-2 (CDM-zizimin homology 2) domain and the DHR-1 or CZH-1domain. For all DOCK proteins, the DHR-1 domain is located N-terminal to the DHR-2 domain. The DHR-1 domain is probably involved in the binding with PtdIns, while the DHR-2 domain may be responsible for the GEF activity through the interaction with Rho GTPase.
View annotated motifs in UniProt.
ModBase predicted 3D structure of Q96N67 from UCSC Gene Sorter: (none).
This protein does not exist in the current release of SWISS-2DPAGE.
Computed theoretical MW=239,422Da, pI=6.34.
(1) Biological process: differentiation, neurogenesis.
(2) Guanine-nucleotide releasing factor, guanyl-nucleotide exchange factor activity.
(3) GTP binding, Rac GTPase binding.
(4) Regulation of pigmentation during development.
Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.
View interactions in HPRD
View co-occured partners in literature searched by PPI Finder.
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac and Cdc42 small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for RhoA. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.